Effect of Bisphenol A on Luteinizing Hormones and Follicle-Stimulating Hormone in Female Rats

Background and Objective: BPA is disruptive to women’s hormone homeostasis. Environmentally relevant doses of BPA can cause effects on human development and reproduction. BPA can impair implantation and impair the establishment of pregnancies leading to a high rate of infertility. BPA may stimulate cell proliferation and stimulates uterine, vaginal and mammary growth. This study investigates the possible effect of BPA on LH and FSH at prevailing low exposure rates in albino Wistar rats. Materials and Methods: Ten experimental groups each containing 10 female rats were administered 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1 mg of BPA/kg body weight, respectively for 3 months. The eleventh control group was given water. Animal blood was collected at the end of every week of the studies and the serum sample specimens were analyzed by routine diagnostic procedures for the parameters assayed. Results: Significantly increased concentrations of luteinizing hormones were observed at all concentrations of BPA exposure and FSH was decreased. Conclusion: The present study is evident that BPA exposure alters the reproductive hormones and this implies that BPA can alter steroid hormone pathways.